Navigating the Depths of RNA Genomics Data
Bioinformatics
Looking for inspiration on your next custom RNA genomics project? Explore our interactive ENCODE RBP-eCLIP reports for your RBPs of interest; read our bioinformatics eBlogs to understand the latest RNA genomics tools; and learn about Eclipsebio’s Lunar™ Data Analysis Portal to help tackle your analysis
Let’s Learn
Download ENCODE datasets analyzed by Eclipsebio for your RBP of Interest
- Reports contain data for peaks and motifs
- Explore analyzed results from over 150 RBPs
- Discover motifs specific for your RBP of interest
- Compare your own results to ENCODE
Lunar Data Analysis Portal: Our Pipelines at your Fingertips
- All users can explore Eclipsebio demo RBP-eCLIP data deliverables in Lunar
- Directly download results or navigate through the data in Lunar’s integrated genome viewer
Read eBlogs by Expert Bioinformatics Scientists
- Interested in how we analyze our different technologies? Learn about new & internally developed bioinformatics tools for our latest RNA genomics technologies
- Gain insights into the different ways Eclipsebio examines data as well as general topics in the field of bioinformatics
Download ENCODE datasets analyzed by Eclipsebio for your RBP of Interest
- Reports contain data for peaks and motifs
- Explore analyzed results from over 150 RBPs
- Discover motifs specific for your RBP of interest
- Compare your own results to ENCODE
Lunar Data Analysis Portal: Our Pipelines at your Fingertips
- All users can explore Eclipsebio demo RBP-eCLIP data deliverables in Lunar
- Directly download results or navigate through the data in Lunar’s integrated genome viewer
Read eBlogs by Expert Bioinformatics Scientists
- Interested in how we analyze our different technologies? Learn about new & internally developed bioinformatics tools for our latest RNA genomics technologies
- Gain insights into the different ways Eclipsebio examines data as well as general topics in the field of bioinformatics
eBlogs Written by RNA Experts
2024 | eBlogs
Discovering miRNA regulation with miR-eCLIP | eBlog
miRNAs are key regulators of expression and translation, however identifying where and how they bind can be a challenge. In this eBlog we reveal how miR-eCLIP can be used to directly profile miRNA activity…[READ MORE]
2024 | eBlogs
Successful mRNA therapeutic design: optimizing for stability and translation | eBlog
mRNA therapeutics have unlocked the potential for rapid responses to infectious disease, personalized treatments for cancer, and protein replacement for different diseases. To ensure efficacy, specific features need to be included in the therapeutic to promote stability, efficient translation, and to… [READ MORE]
2024 | eBlogs
How to find stalled ribosomes | eBlog
Monitoring translation dynamics at the gene level can be effectively achieved by employing ribosome profiling techniques, such as Eclipsebio’s eRibo Pro technology…[READ MORE]
2023 | eBlogs
2023: A Year-in-Review | eBlog
2023 has been an exciting year for RNA and Eclipsebio! The RNA genomics space experienced a number of successes—from fascinating publications to the Nobel Prize in Physiology or Medicine, the importance of RNA to biology and health continues to be… [READ MORE]
2023 | eBlogs
How to Use IGV: Part II | Bioinformatics eBlog
Next-generation sequencing (NGS) libraries produced by Eclipsebio’s assays typically consist of reads derived from targeted RNA regions. A visualization tool allows you to see which genes are present in your samples of interest and, depending on the assay, which specific transcript regions are enriched…[READ MORE]
2023 | eBlogs
Thanksgiving 2023: Thankful for our customers and team | eBlog
As we come towards the end of the year, we at Eclipsebio are taking time this Thanksgiving holiday to reflect on what we are grateful for. As we have asked our fellow team members what they are thankful for, two topics have come up again and again: our customers performing groundbreaking RNA research… [READ MORE]
2023 | eBlogs
Detection of Functional Small Open Reading Frames with Ribosome Profiling | eBlog
Open reading frames (ORFs) are regions of the transcriptome that have an in-frame start and in-frame stop codon. This means that if a ribosome was to start translating at the start codon and translocate every three bases from codon to codon… [READ MORE]
2023 | eBlogs
The Spooky Secrets of Identifying Protein:RNA Interactions | Halloween eBlog
At Eclipsebio, we aren’t afraid of ghosts! Our RBP-eCLIP services can help you obtain meaningful data about your RBP of interest. RBP-eCLIP is a modified version of eCLIP that includes more quality checkpoints throughout the experiment… [READ MORE]
2023 | eBlogs
How to Use IGV | Bioinformatics eBlog
Interpretation and visualization of RNA next-generation sequencing data can be very challenging, but with genomics viewers such as the Integrative Genomics Viewer (IGV), you can easily visualize and explore your data. In this blog we will walk through how to use the desktop application… [READ MORE]
2023 | eBlogs
RBP-eCLIP Motif Calling | Bioinformatics eBlog
The simplest definition of a motif is a short, patterned sequence of nucleotides that play some role in the biology of a system. In the case of RBPs, this role is to bind selectively to defined regions of a given RBP’s protein structure enabling RBPs to target specific transcripts and specific gene features… [READ MORE]
2023 | eBlogs
RBP-eCLIP Peak Annotation | Bioinformatics eBlog
The goal of RBP-eCLIP is to identify where an RNA-binding protein (RBP) is binding; these regions are often called peaks due to their mountain-like appearance on a genome browser. After peaks have been called, it is important to determine what genes and gene features are associated with those sites…. [READ MORE]
2023 | eBlogs
RBP-eCLIP Peak Calling | Bioinformatics eBlog
The simplest definition of a motif is a short, patterned sequence of nucleotides that play some role in the biology of a system. In the case of RBPs, this role is to bind selectively to defined regions of a given RBP’s protein structure enabling RBPs to target specific transcripts and specific gene features…. [READ MORE]
2023 | eBlogs
Stranded Libraries | Bioinformatics eBlog
Forward, reverse, sense, antisense, first strand, second strand, unstranded. Different methods for sequencing RNA-Seq data can lead to differently stranded libraries all with different names. This can make it challenging to figure out how different kits compare to one another or what parameters to use with different software tools to make sure you are doing an analysis correctly…. [READ MORE]
2023 | eBlogs
eRibo Pro Peak Differential Expression | Bioinformatics eBlog
A DE analysis is a statistical procedure that identifies differentially up or downregulated genes between two or more conditions or samples. It involves comparing the expression levels of each gene in one group of samples (e.g., disease samples) to the expression levels in another (e.g., healthy samples) to identify genes that have changed across conditions…. [READ MORE]