My lab had a fantastic experience working with Eclipse BioInnovations. They made the experiment we sought to do approachable, and the staff was available to help and discuss the project every step of the way.

We approached Eclipse Bio because they were the only company that could perform the robust siRNA off-target binding analysis we needed. They were flexible with our needs and they developed all the experimental and computational tools for our project. Their experimental results provided important additional insights into our own internal findings and were clearly presented in a comprehensive report. Eclipse also provided plenty of helpful post-study support when we had questions or wanted to discuss the data. We look forward to continuing to work with Eclipse Bio in the future.

As compared to the other CLIP procedures, the eCLIP kit from Eclipse Bioinnovations includes several steps that improves identification of specific protein-nucleic acid interactions.This kit includes almost all necessary reagents as well as a very detailed protocol with essential explanations of the procedure, suggested stop points and potential trouble for each step of the procedure that makes you well prepared for a relatively long protocol, even if you do not have much experience with CLIP techniques.

I was very impressed by the quality of the libraries. Starting off with roughly 200 ng of mRNA, we obtained high-quality, complex libraries, on the basis of which we were able to identify thousands of m6A sites at single nucleotide precision.