Jason Underwood, PhD

The simplest definition of a motif is a short, patterned sequence of nucleotides that play some role in the biology of a system. In the case of RBPs, this role is to bind selectively to defined regions of a given RBP’s protein structure enabling RBPs to target specific transcripts and specific gene features... [READ MORE]

The simplest definition of a motif is a short, patterned sequence of nucleotides that play some role in the biology of a system. In the case of RBPs, this role is to bind selectively to defined regions of a given RBP’s protein structure enabling RBPs to target specific transcripts and specific gene features.... [READ MORE]

A DE analysis is a statistical procedure that identifies differentially up or downregulated genes between two or more conditions or samples. It involves comparing the expression levels of each gene in one group of samples (e.g., disease samples) to the expression levels in another (e.g., healthy samples) to identify genes that have changed across conditions.... [READ MORE]

The goal of RBP-eCLIP is to identify where an RNA-binding protein (RBP) is binding; these regions are often called peaks due to their mountain-like appearance on a genome browser. After peaks have been called, it is important to determine what genes and gene features are associated with those sites.... [READ MORE]