Surface antigen-guided CRISPR screens identify regulators of myeloid leukemia differentiation.

In this eBlog we discuss the mechanisms of siRNA off-target interactions and outlines strategies to minimize them.

RNA secondary structure is a key determinant of RNA biology and therapeutic efficacy. In this eBlog, we review how RNA structure affects the development of RNA vaccines, siRNAs, and ASOs.

SAN DIEGO, September 3, 2024 — Eclipse Bioinnovations, Inc. (Eclipsebio), the leader in developing precision solutions for RNA-based and RNA-targeting therapeutics, today announced the launch of its eSENSE dsRNA™ assay. eSENSE dsRNA is a next-generation sequencing method for the robust quantification, localization, and optimization of double-stranded RNA (dsRNA) contaminants in RNA-based vaccines and therapeutics. “By […]

dsRNA is an IVT by-product that can limit the efficacy of RNA-based vaccines and therapeutics. In this eBlog, we review how to detect and reduce dsRNA.