eBlogs
Discover insights into RNA biology
and bioinformatics workflows
In our monthly eBlog series, our team of RNA experts discusses the latest advances in RNA therapeutics, key discoveries in RNA biology, and methods for analyzing next-generation sequencing data. Read our blogs below to get insights directly from our wet lab and bioinformatics scientists.
2025 Thanksgiving Message from the CEO
Our CEO, Peter Chu, reflects on the successes of the past year and looks forward to 2025 in this Thanksgiving-themed eBlog.
Reducing off-target effects in siRNA: expert tips for better efficacy
In this eBlog we discuss the mechanisms of siRNA off-target interactions and outlines strategies to minimize them.
RNA structure analysis for improved drug development
RNA secondary structure is a key determinant of RNA biology and therapeutic efficacy. In this eBlog, we review how RNA structure affects the development of RNA vaccines, siRNAs, and ASOs.
dsRNA by-products: a threat to effective RNA-based medicines
dsRNA is an IVT by-product that can limit the efficacy of RNA-based vaccines and therapeutics. In this eBlog, we review how to detect and reduce dsRNA.
Changes in translation: the effect of cell culture and confluency
In this eBlog we review how cell density can affect gene expression and translation.
Characterization is key: how to evaluate mRNA therapeutic safety and efficacy
Before release into the clinic mRNA therapeutics need comprehensive characterization. In this eBlog we review key quality attributes of mRNA therapeutics.