eBlogs
Discover insights into RNA biology
and bioinformatics workflows
In our monthly eBlog series, our team of RNA experts discusses the latest advances in RNA therapeutics, key discoveries in RNA biology, and methods for analyzing next-generation sequencing data. Read our blogs below to get insights directly from our wet lab and bioinformatics scientists.
RNA structure analysis for improved drug development
RNA secondary structure is a key determinant of RNA biology and therapeutic efficacy. In this eBlog, we review how RNA structure affects the development of RNA vaccines, siRNAs, and ASOs.
dsRNA by-products: a threat to effective RNA-based medicines
dsRNA is an IVT by-product that can limit the efficacy of RNA-based vaccines and therapeutics. In this eBlog, we review how to detect and reduce dsRNA.
Changes in translation: the effect of cell culture and confluency
In this eBlog we review how cell density can affect gene expression and translation.
Characterization is key: how to evaluate mRNA therapeutic safety and efficacy
Before release into the clinic mRNA therapeutics need comprehensive characterization. In this eBlog we review key quality attributes of mRNA therapeutics.
Discovering miRNA regulation with miR-eCLIP
miRNAs are key regulators of expression and translation, however identifying where and how they bind can be a challenge. In this eBlog we reveal how miR-eCLIP can be used to directly profile miRNA activity.
Successful mRNA therapeutic design: optimizing for stability and translation
mRNA therapeutics are revolutionizing medicine but the design of an effective RNA can be challenging. In this eBlog we review key design factors.