Capabilities | Eclipsebio

Our capabilities

Unique technologies for unmatched insights

Our portfolio of proprietary technologies and bioinformatics workflows provide actionable insights for therapeutic characterization and optimization. Discover how a partnership with us provides access to unparalleled techniques and analyses.

Empirical data for actionable insights

To solve the needs of our partners, we have developed a comprehensive suite of technologies that provide unparalleled data on key aspects of RNA biology and therapeutic activity. Discover the power of data-based insights over computational predictions.

Bioinformatics

Advanced analyses for actionable insights

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Overview

Use:

Integrative analysis of sequencing data from our portfolio of technologies

Example analyses:

Peak calling, motif identification, differential effects, RNA folding, differential stalling, codon usage

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End-Seq

Discover active UTRs

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Overview

Use:

Assess UTR usage

Typical species:

Human, mouse

Typical samples:

Total RNA

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eRibo Pro

Reveal transcription and translation

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Overview

Use:

Measure transcription (RNA-Seq) and translation (ribosome profiling)

Typical species:

Human, mouse

Typical samples:

Cells, tissues

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eSENSE dsRNA

Measure and reduce dsRNA contamination

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Overview

Use:

Quantify dsRNA, optimize RNA sequences

Typical species:

Viral, human

Typical samples:

IVT RNA

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eSENSE m6A

Locate regions of RNA methylation transcriptome-wide

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Overview

Use:

Map methylated regions

Typical species:

Human, mouse

Typical samples:

Total RNA

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eSHAPE

RNA secondary structure revealed

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Overview

Use:

RNA secondary structure, nucleotide accessibility

Typical species:

Human, mouse, IVT sequences

Typical samples:

In vitro, LNP-encapsulated, and cellular RNA

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m6A-eCLIP

Locate base-specific RNA methylation transcriptome-wide

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Overview

Use:

Map methylated bases

Typical species:

Human, mouse

Typical samples:

Total RNA

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miR-eCLIP

Identify where and how miRNAs and siRNAs bind

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Overview

Use:

Map miRNA and siRNA binding

Typical species:

Human, mouse

Typical samples:

Cells, tissue

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RBP-eCLIP

Map where proteins bind across the transcriptome

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Overview

Use:

Map protein binding sites

Typical species:

Human, mouse, rat

Typical samples:

Cells, tissues

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Need additional support?

At Eclipsebio we value innovation and are continually developing new assays and workflows to improve therapeutic development. If you would like to obtain early access to our newest capabilities or need support that isn’t listed above, contact us today.

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