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Discover the binding patterns of over 150 regulatory proteins
All RNAs in a cell are associated with proteins, and these interactions play a crucial role in RNA biology, influencing RNA stability, splicing, and translation. As part of the ENCODE project, eCLIP was employed to map the binding profiles of over 150 RNA-binding proteins (RBPs) in K562 and HepG2 cells.
Using our RBP-eCLIP analysis pipeline, we've reprocessed the ENCODE data to provide in-depth insights into how and where these proteins bind across the transcriptome, presented through interactive reports. Scroll down to search for your protein of interest and explore its role in gene regulation.
Assay:
RBP-eCLIP
Available datasets:
K562 and HepG2 cell lines
Use:
AI model training, drug design, basic research
Discover
protein binding
For each RBP, we have generated a comprehensive analysis report that includes interactive plots and searchable tables, leading to actionable insights for therapeutic developers and research scientists.
Find enriched gene features
Many RBPs bind to specific regions of genes to regulate activity, such as RBFOX2, which binds to introns to regulate splicing. For each RBP in the ENCODE dataset, we have determined the specific gene features that are bound.
Peak feature enrichment for the RBP RBFOX2
Discover binding motifs
Motifs are short sequences of bases that guide the binding of specific RBPs. Included in each RBP report is a searchable table of identified motifs, including images of the motif itself, the number of peaks containing the motif, and the significance of the enrichment.
Motif enrichment for the RBP RBFOX2.
Locate protein binding sites
When RBP-eCLIP libraries are sequenced, binding sites become enriched within the sequenced reads. We provide an interactive table of each of the binding sites and associated genes.
Location of binding sites across the genome for the RBP RBFOX2.