Our unique portfolio of proprietary technologies provides unparalleled insights into RNA biology. Contact us today to learn how our team can help you achieve your basic research goals.
Contact usBasic Research Solutions
Deep insights into RNA biology require multiomic, data-rich approaches. To support academic researchers investigating key aspects of RNA biology we have developed a portfolio of cutting-edge capabilities that reveal RNA structure, translation, and more. Discover how below.
Basic Research
Eclipsebio was founded to develop unique technologies that provide robust, unparalleled insights into understanding RNA activity and function. To support our academic partners and their groundbreaking discoveries, we have created a portfolio of proprietary assays that reveal different aspects of RNA biology. Learn how our solutions support investigations into multiple aspects of RNA biology, from deep-profiling of a single RNA to transcriptome-wide mapping of miRNA activity.
Contact usStudies of a single gene
Transcriptome-wide studies
Comparing conditions
Explore RNA across multiple dimensions
With our platform of orthogonal technologies, academic researchers can obtain a deeper understanding of RNA biology. We offer solutions to examine regulation, translation, and RNA structure all with in-depth and easy to understand analytical reports.
Determine RNA secondary structure
With our eSHAPE technology we can obtain validated measurements of the RNA secondary structure of a gene in different contexts, including directly after in vitro transcription or within the context of the cell.
Predicted structures do not include the contribution of cellular factors, such as proteins, that can limit accessibility. eSHAPE provides direct evaluation of structure in the cellular environment.
Explore transcription and translation
Within the same assay, eRibo Pro provides information on RNA expression (RNA-Seq) and translation (ribosome profiling). With this information, researchers can gain mechanistic insights into how an experimental change affects a system across multiple dimensions.
Torin 1 suppresses translation of specific genes (right) without affecting RNA levels (left).
Examine miRNA regulation
miRNAs are key regulators of RNA stability and translation. With our miR-eCLIP assay, we directly determine where and how miRNAs bind across the transcriptome. This provides unparalleled insights into miRNA biology and regulation across cell lines and tissues.
Direct detection of miRNA binding in the 3' UTR of E2F3. Each row is a different miRNA and peaks are where the miRNA binds.
Locate regulation by proteins
All RNAs in the cell are bound by proteins that regulate their stability, translation, and localization. With RBP-eCLIP, researchers can determine exactly where a given RNA-binding protein acts including what gene features it binds to and what sequence motifs it recognizes.
Browser tracks showing the binding of a splicing protein in the intron of RTEL1.
Map 5' and 3' UTRs
With different diseases, a given gene can use different UTRs (untranslated regulatory regions outside the coding sequence). Our End-Seq technology directly identifies where UTRs start and end, providing a fuller understanding of how genes are regulated in a given condition.
A unique 5’ UTR is active in cancerous samples and not in healthy samples, making it a potential target for selective regulation in cancer.
Detect RNA modifications
Complexes of RNA-binding proteins write and remove methylation on RNA transcripts, and this methylation has been implicated in a number of critical biological processes. With m6A-eCLIP, we provide per-base resolution of where methylated adenosines are located across the transcriptome.
Browser tracks showing the location of methylated adenosines on C2orf88.
What our
partners say
"My lab had a fantastic experience working with Eclipsebio. They made the experiment we sought to do approachable, and the staff was available to help and discuss the project every step of the way."
Attardi Lab
"Our collaboration with Eclipsebio provided valuable assistance to our research work. Despite resource limitations and the complexities associated with our project focusing on differentiated human embryonic stem cells, the data quality and transparent approach to wet lab validation were noteworthy."
Institute of Human Genetics
“The Eclipsebio team is awesome. They work closely with their customers to ensure the success of their experiments…the Eclipse team designed an experimental pipeline that led to the identification of hundreds of binding RNAs.”
Beliakova-Bethell Lab
"Partnering with Eclipsebio proved to be a significant step forward. In less than a month, we had our data in hand, which was of a high quality and precisely tailored to our needs, even amidst the complexity of human primary cell lines. With their expertise, we were able to uncover a trove of binding sites for our RBP, which has led to new avenues of discovery."