The RNA Sweet Spot
For many years, RNA was the neglected middle child between DNA and proteins. The Human Genome Project and next-generation sequencing revolutionized our ability to analyze and understand DNA. Even before that, researchers were identifying protein targets for small molecules, antibodies and other potentially disease-modifying molecules. While RNA wasn’t cast aside, it wasn’t really promoted for its therapeutic potential.
Now, however, the middle child is finally having its moment. In fact, RNA therapies may hit a sweet spot that DNA and proteins cannot reach: ease of use, scalability, efficacy.
The two COVID-19 mRNA vaccines, which were rapidly produced and highly effective, gave us a glimpse of the possibilities. RNA is continuing to show tremendous promise in other therapeutic areas:
Infectious Disease
Cardiovascular Disease
Cancer
Drug Discovery
In addition to being able to hit new targets, RNA is relatively easy to synthesize and scale. Consider the many challenges associated with making cell lines to produce antibodies and other proteins. Beyond that, RNA provides opportunities for transient gene modulation that far exceed those of their molecular cousins.
Eclipsebio is here to catalyze this revolution. We provide the deep RNA biology and computational expertise companies can use to unlock RNA’s potential. Eclipse’s continuously expanding suite of tools help researchers better understand RNA structure, protein-interactions, modifications and translation into proteins.
These tools are helping scientists answer a wide variety of questions: How are microRNAs interacting with messenger RNA? What can we learn about RNA-binding proteins? Which regulatory and epigenetic mechanisms modulate RNA?
We are leveraging NGS to develop comprehensive solutions that will accelerate scientific and medical breakthroughs, making complicated RNA workflows easy and accessible. These processes are helping companies develop RNA drugs, better understand drug pathways and push the envelope on RNA genomics.
High resolution maps of the RBP-RNA Interactome
Simplified approach to reveal ribosome occupancy transcriptome-wide
High Resolution Maps of the miRNA-mRNA Interactome
High Resolution Maps of the Epitranscriptome
High Resolution Maps of the 5’ and 3’ UTR landscape
A deep sequencing database of SHAPE and ΔSHAPE data
The Eclipsebio team is built from a wide spectrum of scientific and computational disciplines, but we share one common trait: curiosity. For us, everything about RNA is fascinating: its origins, its diverse roles in human biology and its incredible potential for therapeutic success. We are excited to be here.
