Application

Small Molecules

Developing a small molecule compound to target an RNA? Our holistic solutions enable you to examine drug effects across multiple aspects of RNA biology.

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Service Solutions

Use RNA structure to guide design with eSHAPE

  • Focus screening by identifying regions with appropriate accessibility
  • Plan for cellular effects by determining if regions change accessibility in the cellular environment compared to in vitro

Confirm transcription and translation effects with eRibo Pro

  • Confirm on target effects in translation or transcription in the same assay
  • Identify translation specific-effects such as stalls
  • Screen for off target effects in both the transcriptome and translatome

Determine changes in protein binding with RBP-eCLIP

  • If targeting a transcript, determine which proteins bind to the target
  • If targeting an RNA binding protein, confirm changes in binding across the transriptome

Find novel UTRs to target with End-Seq

  • Discover if isoform-specific changes in UTR usage occur after treatment

Determine if miRNA binding is affected with miR-eCLIP

  • Find miRNAs that could compete with your compound
  • Determine if miRNA binding is changed after treatment

Use RNA structure to guide design with eSHAPE

  • Focus screening by identifying regions with appropriate accessibility
  • Plan for cellular effects by determining if regions change accessibility in the cellular environment compared to in vitro

Confirm transcription and translation effects with eRibo Pro

  • Confirm on target effects in translation or transcription in the same assay
  • Identify translation specific-effects such as stalls
  • Screen for off target effects in both the transcriptome and translatome

Determine changes in protein binding with RBP-eCLIP

  • If targeting a transcript, determine which proteins bind to the target
  • If targeting an RNA binding protein, confirm changes in binding across the transriptome

Find novel UTRs to target with End-Seq

  • Discover if isoform-specific changes in UTR usage occur after treatment

Determine if miRNA binding is affected with miR-eCLIP

  • Find miRNAs that could compete with your compound
  • Determine if miRNA binding is changed after treatment