Application

RNAi (siRNA)

Designing an RNAi therapeutic? We have comprehensive solutions to help you design and validate your siRNA.

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Service Solutions

Confirm on target binding and find off targets with miR-eCLIP + siRNA

  • Directly confirm your siRNA binds to the target of interest
  • Screen for off target binding across the entire transcriptome
  • Explore what miRNAs bind to your target

Use RNA structure to guide design with eSHAPE

  • Focus screening by identifying regions with appropriate accessibility
  • Plan for cellular effects by determining if regions change accessibility in the cellular environment compared to in vitro

Examine transcription and translation with eRibo Pro

  • Confirm decreased on target expression after siRNA treatment
  • Screen for off target changes in transcription
  • Determine if siRNA binding affects on and off target translation

Find novel UTRs to target with End-Seq

  • Map the UTR landscape in your sample to find novel regions to target

Explore RNA binding protein interactions with RBP-eCLIP

  • Evaluate if a protein of interest is targeting a similar locus as the siRNA

Confirm on target binding and find off targets with miR-eCLIP + siRNA

  • Directly confirm your siRNA binds to the target of interest
  • Screen for off target binding across the entire transcriptome
  • Explore what miRNAs bind to your target

Use RNA structure to guide design with eSHAPE

  • Focus screening by identifying regions with appropriate accessibility
  • Plan for cellular effects by determining if regions change accessibility in the cellular environment compared to in vitro

Examine transcription and translation with eRibo Pro

  • Confirm decreased on target expression after siRNA treatment
  • Screen for off target changes in transcription
  • Determine if siRNA binding affects on and off target translation

Find novel UTRs to target with End-Seq

  • Map the UTR landscape in your sample to find novel regions to target

Explore RNA binding protein interactions with RBP-eCLIP

  • Evaluate if a protein of interest is targeting a similar locus as the siRNA