Application

mRNA Therapeutics

Developing an mRNA therapeutic including vaccines? Our comprehensive solutions provide information critical for design and quality control.

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Service Solutions

Use RNA structure to guide design with eSHAPE

  • Confirm the RNA folds into an expected structure
  • Evaluate the effects of sequence changes, LNP formulations, and storage conditions on structure

Confirm translation with eRibo Pro

  • Confirm the therapeutic or vaccine is translated
  • Determine if ribosomes stall along the length of the construct

Screen for miRNA regulation with miR-eCLIP

  • Screen for which miRNAs bind to the construct, potentially leading to regulation
  • Determine if modifications to the construct’s sequence change miRNA binding

Find if RNA binding proteins bind with RBP-eCLIP

  • Discover if a specific protein of interest binds to the construct
  • Confirm potential translation suppressors do not bind

Determine if the therapeutic is modified with m6A-eCLIP

  • Identify if the construct gains methylated adenosines after introduction to the cellular environment

Use RNA structure to guide design with eSHAPE

  • Confirm the RNA folds into an expected structure
  • Evaluate the effects of sequence changes, LNP formulations, and storage conditions on structure

Confirm translation with eRibo Pro

  • Confirm the therapeutic or vaccine is translated
  • Determine if ribosomes stall along the length of the construct

Screen for miRNA regulation with miR-eCLIP

  • Screen for which miRNAs bind to the construct, potentially leading to regulation
  • Determine if modifications to the construct’s sequence change miRNA binding

Find if RNA binding proteins bind with RBP-eCLIP

  • Discover if a specific protein of interest binds to the construct
  • Confirm potential translation suppressors do not bind

Determine if the therapeutic is modified with m6A-eCLIP

  • Identify if the construct gains methylated adenosines after introduction to the cellular environment