We are proud to share two recent publications by Eclipse Bio customers!
Our eCLIP service was used to determine RBM39 function in AML maintenance (Wang et al., 2019), and helped to identify PEG10 binding targets (Abed et al., 2019).
- RBM39 is required for AML maintenance through mis-splicing of HOXA9 target genes.
- Proteomic studies identify an essential RBP splicing network in AML.
- Pharmacologic RBM39 degradation leads to broad anti-leukemic effects
- PLOS ONE: The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification.
- PEG10 interacted with the 3′ untranslated regions (UTRs) of many mRNAs.
- Expression of Hbegf was reduced in PEG10-deficient TSCs suggesting that PEG10 might bind to and stabilize RNAs that are critical for normal placental development.
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