N(6)-methyladenosine (m6A)

First discovered in 1974, N(6)-methyladenosine (m6A) is now recognized as the most prevalent post-transcriptional modification on RNA in higher eukaryotes and has been implicated as a key feature in numerous RNA processing steps.

m6A modifications are highly dynamic, and are actively and differentially regulated across tissues and conditions by families of proteins that catalyze their addition, recognition, and removal from RNA.

Dysregulation of m6A at many of these steps have been correlated to physiological diseases including obesity and cancer, making the rapid, systemic-profiling of m6A a high priority in both basic research attempting to understand the full regulation and effects of m6A-modifications as well as in therapeutics potentially looking to target the m6A system.

If you’re interested in learning more about m6A modifications, how to identify and characterize them or how you can incorporate them into your research, visit our m6A site.